agrin in postsynaptic differentiation
| PAG Title | agrin in postsynaptic differentiation |
| PAG ID | WAG001453 |
| Type | P |
| Source Link |  BioCarta |
| Publication Reference | NA |
| PAG Description | The heparan sulphate proteoglycan agrin is well known as the key assembly factor of postsyptic differentiation at the neuromuscular junction (NMJ), but recent data suggest it also plays a direct role in the organization of the cytoskeleton in the skeletal muscle. Sigling through muscle-specific proteins such as muscle specific kise (MuSK) and or acetylcholine receptor (AchRs)/rapsyn, agrin can activate ubiquitously expressed Rac, Cdc42, and p21-activated kise (PAK) that are involved in actin polymerization. Agrin also engages sigling pathways of several potent oncogenes (i.e., SFK, ErbB receptors, and cortactin). |
| Species | Homo sapiens |
| Quality Metric Scores | nCoCo Score: 2,155 |
| Information Content | Rich |
| Other IDs | |
| Base PAG ID | WAG001453 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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